When nerves are the target for treatment, as in the case of the pain disorder trigeminal neuralgia, radiosurgery diminishes the function of improperly acting nerves, which provides relief.

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For blood vessel malformations, such as an arteriovenous malformation, Gamma Knife treatment causes the malformed blood vessels gradually to close off.

Radiosurgery for tumor treatment works by damaging or destroying the DNA of tumor cells so that these cells cannot reproduce or grow. Over time, the brain tumor shrinks.